This section of our pharmaverse recommended list is dedicated to those packages less relevant for individual clinical reporting end users, and instead more relevant to other roles such as package developers or admins maintaining package repositories.

Package Validation

Validation and qualification are two important topics in regulatory interactions. For R package validation, there are example tools like covtracer to automate via CI/CD tools validation (and re-validation) of packages once we feel the quality of their documentation and unit testing is sufficient. thevalidatoR represents a simplified version of this approach. There are also packages to support decisions around risk assessment when approaching validation strategy for R packages.

covtracer

Automated tracing of code coverage via a network of test execution, linking tests to code & code to documentation. This package is used to provide the tracebility matrix for CICD based validation.

valtools

Validation framework for R packages that allows you to bolt in additional validation documentation.

riskmetric

Framework to quantify R package risk by assessing a number of meaningful metrics.

riskassessment

Shiny utility for riskmetric.

CI/CD

Continuous Integration / Continuous Deployment and other DevOps methods can hugely help package developers with efficiency saving, by reducing manual steps.

Under the pharmaverse GitHub org we have admiralci which offers re-usable GitHub action workflows that may be useful to any pharmaverse package. Outside of this there is a PHUSE WG looking to broaden this for greater community benefit.

For a GitHub specific CI example related to package validation see:

thevalidatoR

A GitHub action on the GitHub Marketplace to provide standardised build reports for validation. An alternative approach to valtools that relies on the normal R framework for validation.

Synthetic Data

Generating CDISC standards synthetic data for use when developing and testing R packages can be a painful but often necessary part of building clinical reporting R packages.

We offer the following packages that as a basis re-used SDTM data from the CDISC pilot project, with added therapeutic area specifics such as oncology domains. These have then been ran through {admiral} templates to provide consistent ADaM test data.

pharmaversesdtm

Test data (SDTM) for the pharmaverse family of packages

pharmaverseadam

Test data (ADaM) for the pharmaverse family of packages

Developer Utilities

{admiraldev} offers numerous developer utilities focused on the {admiral} family of packages, but some could be useful to re-use. Take a look at the reference page to explore further.

There is an ongoing effort {roxytractor} to extract information from {roxygen2} documentation within R packages, simplifying the process of converting documentation into structured data efficiently. This could be useful in activities such as training GenAI/LLM solutions.